Name: Italian Penicillin Soup
Prep time: 10 min
Cook time: 25 min
Total time: 35 min
Cuisine: Italian-American
Ingredients: 1 tablespoon olive oil; 1 small onion, diced; 2 cloves garlic, minced; 2 carrots, sliced; 2 celery stalks, sliced; 1 teaspoon dried oregano; 1/2 teaspoon red pepper flakes (optional); 6 cups chicken broth; 2 cups cooked shredded chicken (rotisserie or leftover); 1 cup small pasta (like ditalini or orzo); 1 tablespoon lemon juice; Salt and black pepper to taste; 1/4 cup fresh parsley, chopped; Freshly grated Parmesan cheese for garnish (optional)

Jump to Recipe

Italian Penicillin Soup is a hearty, flavorful, and comforting dish inspired by the traditional Jewish penicillin (chicken soup) but with bold Italian influences. It’s often made with chicken, vegetables, pasta or rice, garlic, and aromatic herbs. This nourishing soup is a go-to recipe for soothing colds, warming up on chilly days, or simply enjoying a delicious homemade meal.

Why You’ll Love This Recipe

This Italian Penicillin Soup combines the healing comfort of chicken soup with the rich, herbaceous flair of Italian cuisine. The recipe is incredibly versatile, easy to prepare, and packed with nourishing ingredients. Whether you’re feeling under the weather or craving a warm, satisfying meal, this soup hits the spot. The blend of garlic, rosemary, and Parmesan offers a depth of flavor that’s both restorative and indulgent.

ingredients

(Tip: You can find the complete list of ingredients and their measurements in the recipe card below.)

Olive oil
Onion
Carrots
Celery
Garlic
Fresh rosemary
Boneless, skinless chicken thighs or breasts
Chicken broth
Diced tomatoes
Orzo or small pasta
Fresh spinach or kale
Parmesan rind (optional but recommended)
Salt and pepper
Fresh parsley
Grated Parmesan cheese for serving

directions

In a large pot, heat olive oil over medium heat. Add chopped onions, carrots, and celery. Sauté until the vegetables are softened.
Add minced garlic and rosemary, cooking until fragrant.
Place the chicken into the pot and pour in the chicken broth and diced tomatoes. Bring to a boil.
Lower the heat, add the Parmesan rind (if using), and let it simmer for 20-25 minutes, or until the chicken is cooked through.
Remove the chicken, shred it using two forks, and return it to the pot.
Stir in the pasta and simmer until it is al dente, about 8-10 minutes.
Add spinach or kale, and cook just until wilted.
Season with salt and pepper to taste.
Ladle into bowls and garnish with chopped parsley and grated Parmesan cheese before serving.

Servings and timing

This recipe yields approximately 6 servings.
Prep Time: 15 minutes
Cook Time: 35 minutes
Total Time: 50 minutes

Variations

Vegetarian Option: Use vegetable broth and omit the chicken, replacing it with cannellini beans for protein.
Spicy Kick: Add a pinch of red pepper flakes during the sautéing process.
Lemon Twist: Finish the soup with a squeeze of fresh lemon juice for added brightness.
Different Greens: Try escarole or Swiss chard in place of spinach or kale.
Gluten-Free: Use gluten-free pasta or cooked rice instead of orzo.

storage/reheating

Allow the soup to cool completely before storing it in an airtight container.
Refrigerator: Keeps well for up to 4 days.
Freezer: Freeze for up to 3 months. Store without the pasta if possible, as it may become mushy when thawed. Add freshly cooked pasta upon reheating.
Reheating: Warm over medium heat on the stovetop or in the microwave, stirring occasionally. Add broth if needed to adjust the consistency.

FAQs

What is Italian Penicillin Soup?

It’s a comforting chicken-based soup with Italian seasonings, vegetables, and pasta, often used as a home remedy for colds.

Can I use rotisserie chicken instead of cooking raw chicken?

Yes, shredded rotisserie chicken can be stirred in during the final few minutes to heat through.

Is Parmesan rind necessary?

No, but it adds a rich, savory depth to the soup that enhances the overall flavor.

Can I make this in a slow cooker?

Yes. Add all ingredients except the pasta and spinach. Cook on low for 6-7 hours, then add pasta and greens for the last 30 minutes.

What can I use instead of orzo?

Small pasta shapes like ditalini, acini di pepe, or even rice work well.

How can I make it more filling?

Add more vegetables or beans like chickpeas or cannellini for added bulk and nutrition.

Can I make it dairy-free?

Yes, omit the Parmesan rind and grated cheese garnish for a dairy-free version.

How do I prevent the pasta from getting soggy?

Cook the pasta separately and add it to each bowl before serving, especially if storing leftovers.

What herbs go well with this soup?

Rosemary, thyme, and parsley are classic, but basil or oregano can be used for variation.

Is this soup good for colds?

Yes, the warm broth, garlic, and herbs make it a soothing and nutritious remedy for cold symptoms.

Conclusion

Italian Penicillin Soup is a comforting and flavorful take on a traditional remedy that combines wholesome ingredients and Italian-inspired seasonings. Perfect for family dinners or healing days at home, it offers both nourishment and delicious satisfaction. Whether you’re seeking warmth or wellness, this soup is sure to deliver